ABSTRACT
Arnica montana 6CH is a medicine indicated for inflammatory and painful conditions, especially in muscle structures. The RDC / TMD Axis II questionnaire is a validated tool for the diagnosis of Temporomandibular Muscle Dysfunction. Objective: This multicenter, randomized and controlled study, approved by Human or Animal Research Ethics Committee UniFOA -CAAE: 48680015.3.0000.5237 aimed to verify the clinical performance of Arnica montana 6CH in contractures and muscle pain triggered by isometric stress. Materials and Methods: 70 patients underwent prolongeddental treatment sessions, and they were selected after clinical examination and positive responses to the RDC / TMD questionnaire to confirm signs and symptoms of Temporomandibular Muscle Dysfunction at the first consultation. Randomly, Arnica montana 6CH was prescribed for 35 patients called group I, and placebo for 35 patients called group II, at a dose of 5 globules, 03 times a day, for 1 week. In the second endodontic consultation, after 15 days, a new clinical examination was performed at the beginning and end of the prolonged dental consultation with crossing of data from the RDC questionnaire, to monitor the prevalence of TMD muscle signs and symptoms. The data were tabulated and analyzed. Statistical analysis: The test t de Student was used for paired samples, significant at the level ≤ 0.05%. Results:Anamnetic data from the RDC questionnaire, 86% of the individuals in the GI had lower pain and muscle contracture rates in the second consultation, compared with 22% in the GII. Conclusion:The drug Arnica montana 6CH proved to be effective in preventing muscle changes and clinical symptoms resulting from isometric efforts with a statistically significant difference (p ≤ 0.05).
Subject(s)
Humans , Arnica , Oral Surgical Procedures/rehabilitation , Myalgia/therapy , ThermographyABSTRACT
Background: Anxiety affects around 7.3% of the total population worldwide. Benzodiazepines are preferred anxiolytic agents and are still frequently used in spite of the side effect profile including muscle relaxation, memory disturbances, sedation, physical dependence. Arnica montana, a traditional herb is known to possess significant anxiolytic effect at the dose of 100mg/kg. In this study, Arnica montana has been compared for the first time with alprazolam, a most commonly used anxiolytic drug.Methods: Forced swim test was used to induce anxiety. Anxiolytic action of study drugs which were given orally, was evaluated using Open field test (OFT) in healthy wistar rats of either sex. Behavior of rats, locomotion and number of squares crossed was recorded. Rats were divided into four groups with eight rats in each group. Study groups were Group I Control; Group II Alprazolam 0.08mg/kg; Group III Arnica montana extract (AME) 100mg/kg; Group IV AME + Alprazolam group 100mg/kg+0.08mg/kg. Statistical analysis was done using ANOVA followed by Tukey抯 test (p<0.05).Results: Increase in frequency of rearing was significant (p<0.05) in AME group and highly significant (p<0.001) in Alprazolam and combination group in comparison to control. Decrease in frequency of grooming was highly significant (p<0.001) in Alprazolam and combination group. AME also showed significant (p<0.05) decrease in grooming activity.Conclusions: Arnica montana extract showed anxiolytic activity and can be used as an add on drug after further studies and validation in the treatment of anxiety disorders.
ABSTRACT
Arnica montana is a popular traditional remedy widely used in complementary and alternative medicine, in part for its wound-healing properties. The authors recently showed that this plant extract and several of its homeopathic dilutions are able to modify the expression of a series of genes involved in inflammation and connective tissue regeneration. Their studies opened a debate, including criticisms to the "errors" in the methods used and the "confounders and biases". Here the authors show that the criticisms raised on methodology and statistics are not consistent and cannot be considered pertinent. The present comment also updates and reviews information concerning the action of A. montana dilutions in human macrophage cells while summarizing the major experimental advances reported on this interesting medicinal plant.
ABSTRACT
Se presenta un caso de trauma dentoalveolar en un paciente masculino de 22 años de edad, al sufrir un asalto en la Ciudad de México. El paciente acude al consultorio dental 29 horas posteriores al incidente; durante la exploración se identifican edema y laceraciones en los labios; movilidad de los dientes centrales superiores y fractura del ángulo mesio-incisal del lateral superior derecho. El estudio radiográfico muestra fractura de las coronas en los centrales superiores. El abordaje terapéutico combinó Homeopatía, tratamiento endodóntico, periodontal y prótesis. Los medicamentos que se administraron fueron: Arnica montana, Hypericum perforatum, Calendula officinalis y Echinacea angustifolia (nombre de marca: Gavosim); se prescindió de antibióticos y antiinflamatorios. A las cuatro semanas del tratamiento endodóntico se remitió al paciente con el periodoncista, y cuatro semanas después, con el protesista. Al final, se logró la rehabilitación total. Se concluye que los medicamentos prescritos facilitaron la recuperación de los tejidos periodontales.
Subject(s)
Humans , Male , Periodontal Diseases , Homeopathic Remedy , Homeopathy , Dental Health ServicesABSTRACT
Objetivo: Dados estatísticos nacionais e mundiais demonstram que o número de indivíduos idosos tende a crescer de maneira exponencial nos próximos anos, tornando-se uma população significativamente e proporcionalmente maior que as demais. Entre as doenças mais comuns nessa faixa estaria encontra-se a osteoporose, doença que reduz a massa esquelética e deteriora a microarquitetura do osso causando fragilidade e aumentando o risco de fraturas. Material e Métodos: Este estudo teve como proposta avaliar o efeito da Arnica montana fitoterápica e homeopática no reparo de lesões ósseas, visando uma possível forma de tratamento de fraturas na vigência da osteoporose. Os ensaios experimentais foram realizados em ratas Wistar adultas, divididas em quatro grupos: ovariectomizado tratado com Arnica montana 6CH homeopática (OVZ 6CH); ovariectomizado tratado com extrato fitoterápico de Arnica montana (OVZ TM); ovariectomizada tratado com placebo (OVZ PL) falsa cirurgia de ovariectomia e tratado com placebo (Sham PL). Após 45 dias da cirurgia sham ou de ovariectomia, foi realizada uma lesão óssea monocortical. Os animais foram eutanasiados após 6, 12, 18 e 28 dias e as tíbias retiradas para avaliação das suas dimensões e analise do reparo ósseo através de densidade óssea radiográfica, ensaios biomecânicos e microscopia eletrônica de varredura (MEV). Os dados do teste de flexão foram submetidos à analise estatística pelos testes de ANOVA e Tukey (p< 5%). Resultados: Conclui-se que o tratamento com arnica 6CH foi melhor que o com arnica TM quanto à resistência e à qualidade de regeneração óssea, enquanto a TM mostrou melhor valor de densidade óptica. Conclusão: Esse estudo concluiu que o tratamento com Arnica montana homeopática foi mais eficiente que com Arnica fitoterápica na regeneração óssea de ratas com osteoporose (AU)
Objective: National and international data show that in the next years the elder population tends to have an exponential increase becoming to be significantly higher than other ages. Among the frequent diseases in the elderly, osteoporosis is a disease that decreases bone mass and deteriorates bone structure causing fragility and a high risk of fracture. This study aimed to evaluate the effect of phytotherapic and homeopathic Arnica montana on bone repair quality and its possible use in the treatment of bone fracture in patients with osteoporosis. Material and Methods: This experimental study was performed in Wistar adult female rats divided in 4 groups according to the following treatments: ovariectomized treated with homeopathic A. montana 6CH (OVZ 6CH); ovariectomized treated with phytotherapic A. montana (OVZ TM); ovariectomized with placebo (OVZ PL) and rats with sham surgery and placebo (Sham PL). In a period of 45 days after ovariectomy or sham surgery, all animals got a monocortical lesion. They were euthanized after 6, 12, 18 and 28 days and had the tibiae removed to evaluate dimensions and bone repair by radiographic density, biomechanical test and scanning electronic microscopy (SEM). Data were analyzed by ANOVA and TUKEY tests (p < 0.05). Results: Results showed that treatment with Arnica 6CH was better than Arnica TM considering bone resistance and bone repair quality. Conclusion: This study concluded that treatment with homeopathic A. montana was more efficient than with phytotherapic Arnica in bone regeneration in rats with osteoporosis.(AU)
Subject(s)
Animals , Rats , Arnica , Osteoporosis , Phytotherapy , RadiographyABSTRACT
@#<p><strong>OBJECTIVE:</strong>To determine the association of Arnica montana and blood loss, surgical field bleeding and operative time in endoscopic sinus surgery among adults with chronic rhinosinusitis with nasal polyposis.</p> <p><strong>METHODS:</p></strong> <p><strong>Design:</strong> Single-blinded Randomized Controlled Trial</p> <p><strong>Setting:</strong> Tertiary government hospital</p> <p><strong>Participants:</strong> Forty-one (41) adults aged 19-76 years old with chronic rhinosinusitis with nasal polyposis and meeting inclusion criteria were randomly divided into two groups, Arnica and control. The former took 5 sublingual Boiron® Arnica montana 30C pellets, 12 hours then 1 hour prior to surgery; the latter did not. Both groups had routine oxymetazoline and lidocaine-epinephrine decongestion. Intraoperative blood loss, surgical field bleeding quality and operative time were assessed by blinded surgeons and anesthesiologists. </p> <p><strong>RESULTS:</strong> Mean estimated blood loss was 187ml (SD 100.14) for controls versus 72ml (SD 12.59) for the Arnica group; (p < 0.05). Mean operative time was 3.55 hours (SD 1.25) for controls and 3.44 hours (SD 1.57) for the Arnica group; (p=0.9). Surgical field bleeding was graded slight with 75% needing occasional suctioning (grade 2) and 25% needing frequent suctioning (grade 3) in the Arnica group, versus moderate bleeding with more frequent suctioning (grade 4) in 71% and slight bleeding but needing frequent suctioning (grade 3) in 29% of controls.</p> <p><strong>CONCLUSION:</strong> In this randomized clinical trial, Arnica montana was associated with less blood loss and less surgical field bleeding compared to controls, but there was no difference in mean operative times. Arnica montana may be effective in reducing blood loss and improving surgical field quality during endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis.</p> <p> </p>
Subject(s)
Humans , Male , Female , Aged , Middle Aged , Adult , Hemostasis , OxymetazolineABSTRACT
BACKGROUND: Studies have shown that Arnica montana shows anti-inflammatory and antioxidant activities. It has been used in traditional medicine for the treatment of several disorders. The aim of this study was to investigate the effect of Arnica montana on mast cells during the wound healing of oral ulcers. METHOD: An ulcerated lesion was chemically induced on the tongue of 75 male albino rats and, then, treated topically for seven days using saline solution (control), Arnica montana gel or tincture. The animals were killed after 2nd, 7th, 14th, 21th and 42th day of treatment. The tongues were removed and subjected to routine laboratory (0.2% toluidine blue staining). The numbers of mast cell were determined in two regions: superficial and submucosa. RESULTS: The numbers of mast cells were significantly increased for all groups in the region of the deeper tissue when compared to the superficial region. No statistical difference was observed in mast cell numbers for each group. CONCLUSION: This study revealed that Arnica montana tincture and gel were unable to change mast cell population during wound healing of oral ulcer of rats. According to these results, the anti-inflammatory effects of Arnica montana were not related to inhibition of mast cell degranulation.
OBJETIVO: Sabe-se que a Arnica montana mostra atividade anti-inflamatória e anti-oxidante e tem sido usada em medicina tradicional para o tratamento de vários distúrbios. O objetivo deste estudo foi investigar o efeito da Arnica montana em mastócitos durante a cicatrização de feridas de úlceras orais. MÉTODO: Uma úlcera foi quimicamente induzida na língua de 75 ratos albinos machos e, em seguida, tratada topicamente durante sete dias, utilizando solução salina (controle), gel ou tintura de Arnica montana. Os animais foram sacrificados após 2, 7, 14, 21 e 42º dia de tratamento. As línguas foram removidas e submetidas a rotina de laboratório (coloração com 0,2% de azul de toluidina). A densidade de mastócitos foi determinada em duas regiões: superficial e submucosa. RESULTADOS: O número de mastócitos aumentou nitidamente para todos os grupos na região mais profunda do tecido peri-ulceroso, quando comparada à região superficial. Nenhuma diferença estatística foi observada no número de mastócitos entre os grupos. CONCLUSÃO: Este estudo revelou que a tintura ou o gel de Arnica montana foram incapazes de interferir na população de mastócitos durante a cicatrização da úlcera oral de ratos. De acordo com estes resultados, os efeitos anti-inflamatórios de Arnica montana não foram relacionados à inibição da degranulação dos mastócitos.
Subject(s)
Animals , Rats , Wound Healing/drug effects , Arnica , Oral Ulcer/therapy , Mast Cells , Rats, Inbred StrainsABSTRACT
Se realizó un estudio de intervención terapéutica en 80 pacientes con dolor luego de la extracción de terceros molares retenidos, en el Hospital Provincial Docente Clinicoquirúrgico "José Ramón López Tabrane" de la provincia de Matanzas, desde enero del 2012 hasta igual mes del 2013, con vistas a evaluar la evolución de estos. Para ello se formaron 2 grupos de 40 integrantes cada uno; a uno se le indicó tratamiento convencional con dipirona de 300 mg (grupo de control) y al otro, homeopatía con Arnica montana en 30 ch (grupo experimental). Los resultados demostraron la existencia de una terapia alternativa que podría ser utilizada cuando los medicamentos de primera elección hayan fallado, ya sea por su baja eficacia o por la aparición de reacciones adversas. En los pacientes tratados con Arnica montana, el efecto fue satisfactorio; además, este remedio homeopático es seguro y menos costoso para el Sistema Nacional de Salud cubano.
A therapeutic intervention study was carried out in 80 patients with pain after the extraction of third retained molars, in "José Ramón López Tabrane" Teaching Provincial Clinical-Surgical Hospital in Matanzas province, from January, 2012 to the same month of 2013, with the objective of evaluating their clinical course. For this purpose, 2 groups of 40 members each were formed; conventional treatment with dipyrone of 300 mg (control group) was indicated to one of them, and to the other homeopathy with Arnica montana in 30 ch (experimental group). The results demonstrated the existence of an alternative therapy that could be used when first election drugs have failed, either for their low effectiveness or for the emergence of adverse reactions. In the patients treated with Arnica montana, the effect was satisfactory; also, it can be said that this homeopathic remedy is safe and less expensive for the Cuban National Health System.
Subject(s)
Tooth, Impacted , Arnica , Molar, Third , Dipyrone , Homeopathy , Medicine, TraditionalABSTRACT
Se realizó un estudio de intervención terapéutica en el módulo de San Benito de Mayarí, provincia de Santiago de Cuba, en el primer cuatrimestre de 2010, a fin de evaluar la evolución de 72 pacientes con estomatitis subprótesis de grados I y II, distribuidos de forma alterna en 2 grupos: en el A se incluyeron los números impares, con terapéutica convencional; y en el B los pares, con tratamiento homeopático. En ambos grupos predominaron los integrantes de 45-54 años y del sexo femenino, así como los curados al tercer día (72,2 y 80,6 %, respectivamente). El tratamiento homeopático con árnica montana en pacientes con estomatitis subprótesis de grados I y II, fue tan beneficioso como la terapéutica convencional en igual tiempo de evolución y estuvo exento de reacciones adversas, lo cual justificó el uso de esta modalidad terapéutica, que al igual que otras de la medicina natural y tradicional, es inocua, económica y de fácil acceso.
A study of therapeutic intervention in the module of San Benito, from Mayarí, II Frente municipality, Santiago de Cuba province was carried out in the first quarter of 2010, in order to evaluate the clinical course of 72 patients with denture stomatitis of grades I and II, alternatively distributed in 2 groups: in group A the odd numbers were included, with conventional therapy; and in group B the pairs, with treatment. In both groups the members of 45-54 years and female sex prevailed, as well as those cured at the third day (72.2 and 80.6%, respectively). The homeopathic treatment with arnica montana was as beneficial as the conventional therapy in same time for the clinical course and it had no adverse reactions, what justifies the use of this therapeutic modality which as others modalities of the natural and traditional medicine, it is innocuous, economic and of easy access.
Subject(s)
Stomatitis , Dental Prosthesis , Arnica , Homeopathy , Medicine, TraditionalABSTRACT
Comunicamos un caso de dermatitis por contacto severa debida al Árnica montana, en una paciente con antecedentes de hipertensión arterial tratada regularmente y controlada; se enfatiza la importancia de un control evolutivo, examen físico semiológico completo y los diagnósticos diferenciales, de estas variantes severas e infrecuentes.
The presentation of a case of irritant contact dermatitis in a patient with a history of high blood pressure regularly treated and controlled, who starts on 19.04.13 with fever of 39º5 which ceded with use of current antipyretic; accompanied by myalgia, retro-ocular pain, arthralgias, headache of strong intensity, complete haematology reports thrombocytopenia and leukocytosis at the expense of segmented, picture that remained for 48 hours; later is associated with stabbing pain and right lower limb rigidity. 22.04.13 presents increase in volume and signs of phlogosis of elevated erythematous edges that extends to the sural region, with blister on right twin region of approximately 10x10 cm with functional limitation of that member. The patient is hospitalized under the diagnosis of Bullous erysipelas, receives broad spectrum antibiotics to Gram +, Gram - and anaerobic. 29.04.13 blister hatches draining not foul-smelling yellowish secretion; it is cultivated and Gram, reporting no bacterial growth. Refers to Central Hospital of Maracay entering it with the diagnosis of cellulitis blistering, where it performed second Gram and cultivation reported without bacterial growth; they perform a biopsy which reports epidermal necrotic dermatitis superficial and deep compatible with dermatitis irritant contact. The case is reevaluated, interrogating again to the patient and the dermal symptoms coincide with the use of Árnica montana product (this data was not reported or questioned in the initial history). Update about the product reported that exists extensive reference on cases of dermatitis contact, mainly by the use of Árnica montana and one of its components; methylparaben, these cases have been reported by prolonged use of the product described as excited skin syndrome or angry back. The patient after to the second questioned referred the use of this product frequently for several years topically and even concerned using infusions of the flower of Árnica montana orally. It was decided to deal with steroids intravenously, resulting in evident improvement with egress to the fifth day and outpatient follow-up, which reported complete remission of picture.
ABSTRACT
El Arnica montana es uno de los medicamentos que se emplean con mayor frecuencia en la práctica homeopática. Comúnmente, es la primera elección en la atención de traumatismos, contusiones y golpes, especialmente de partes blandas. También se emplea en torceduras, fracturas, esfuerzos exagerados, enfermedades reumáticas, traumas emocionales y para mejorar la recuperación de los pacientes que se someten a intervenciones quirúrgicas. Debido al interés que genera, el Arnica montana ha sido objeto de numerosos estudios en diferentes áreas para comprobar su alcance y determinar sus mecanismos de acción. A continuación se presenta una revisión de algunos artículos publicados sobre este medicamento; unos versan sobre sus principios activos y otros analizan diversos experimentos que se han efectuado.
Arnica montana is one of the most often used drugs in homeopathic practice. Commonly, it is the first choice in the trauma care, bruises and bumps, especially soft tissue. Also used in sprains, fractures, exaggerated efforts, rheumatic diseases and emotional trauma to improve recovery of patients who undergo surgery. Due to the interest generated, Arnica montana has been the subject of numerous studies in different areas to check their range and determine their mechanisms of action. Below is a review of some articles published on this medication, some deal with other active principles and discusses various experiments that have been conducted.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , /pharmacology , Biochemistry , Pharmacodynamics of Homeopathic Remedy , Homeopathy , LactonesABSTRACT
La homeopatía es considerado un sistema médico complejo estructurado en términos teóricos y simbólicos configurando una racionalidad médica de la morfología humana basada en la doctrina del vitalismo que se rige por los principios de la individualidad la similitud y la experimentación pura y las dosis infinitesimales. El Árnica Montana una planta denominada así primariamente por ser encontrada en las montañas y sus hábitat natural es en la península escandinava, sur de Europa, Norteamérica entre otros. Ha sido utilizada por propiedades farmacológicas básicas como analgésico y antiinflamatorio. El objetivo de este trabajo es determinar el efecto del árnica montana en su forma homeopática en la viabilidad celular y la regulación de IL6 sobre las células mononucleares de personas sanas in vitro. Esto en diluciones homeopáticas (6CH, 15CH, 30CH, 60CH, 200CH, y 1000CH). Los resultados mostraron que el árnica montana tiene un efecto proliferativo sobre las células mononucleares de pacientes sanos en las diferentes diluciones a las 48 y 72 horas es de anota que en la 200CH y 1000 CH son estadísticamente significativas. En cuanto a la cuantificación de IL6 se observa que responden de una manera diferente a cada una de las diluciones pero se conserva que a la dilución 200CH y 1000CH son las que producen mayor cantidad de IL6. Vemos claramente que las diferentes diluciones tienen diferentes respuestas en los diferentes individuos confirmando el principio de la individualidad premisa fundamental y básica de la homeopatía.
Subject(s)
Humans , Adult , T-Lymphocytes , /pharmacology , Cytokines/therapeutic use , In Vitro Techniques , Immunosuppressive Agents , Anti-Inflammatory AgentsABSTRACT
As desordens musculares geralmente estão presentes na Disfunção Temporomandibular (DTM). Sua principal sintomatologia é dor, edema, proveniente de injúria tecidual e inflamação. O tratamento das DTMs consiste em tratamento suporte para alívio da sintomatologia e definitivo para eliminar as causas e fatores que são perpetuantes. O uso de antiinflamatórios (AINEs), relaxantes musculares, placas oclusais, fitoterápicos com ação antiinflamatória como Arnica Montana são indicados como tratamento suporte. A Arnica montana tem sido usada para redução de inflamação e dor causada por entorse, contusões e ferimentos. Sua principal ação é inibição da ativaçãodo fator de transcrição celular NF- қB.
Subject(s)
/therapeutic use , Muscular Diseases/therapy , Facial Pain/therapy , Inflammation/therapy , Temporomandibular Joint Dysfunction Syndrome/therapyABSTRACT
Objetivo: Avaliar a ação do medicamento homeopático Arnica montana 6 cH comparada ao Diclofenaco Sódico 50mg no controle do edema após remoção de terceiros molares inclusos. Métodos: O trabalho tratou-se de uma pesquisa experimental, cruzada, randomizada, duplo-cega, realizada em 30 alunos voluntários do curso de Odontologia da Universidade Federal de Sergipe, com presença de dentes inclusos em bilaterais, perfazendo um total de 120 dentes, com indicação da mesma técnica cirúrgica exodôntica. Os grupos foram divididos em Grupo A: os que usaram a Arnica Montana 6cH e Grupo D: os que usaram Diclofenaco de Sódio 50mg. Para a mensuração do edema, foi utilizada uma fita métrica com a qual foram tomadas três medidas como referência: 1) canto de olho ao tragus (CO-T); 2) canto de olho ao ângulo da mandíbula (CO-AM); 3) comissura labial ao tragus (CL-T). Estas foram realizadas quatro vezes sendo a primeira logo após o fim do procedimento cirúrgico, e as demais após 24h, 48h e 72h da cirurgia. O teste de Shapiro-Wilk foi usado para verificação da distribuição normal das variáveis. Nas variáveis que apresentaram dados paramétricos foi usado o teste de comparação de Student. Os dados foram considerados estatisticamente significantes quando p menor que 0,05. Resultados: No período de 48h pós-cirurgia, o edema foi mais marcante para ambos os grupos nos segmentos CO-AM e CL-T. Após 72h ocorreu uma regressão do edema para ambas as medicações testadas. O segmento que menos apresentou edema foi o CO-T para as duas medicações. O teste de Student mostrou que as medicações se equivalem na efetividade anti-edematosa (p maior que 0,05). Conclusão: O medicamento homeopático Arnica montana 6 cH possui eficácia no controle do edema pós-extração de terceiros molares inclusos. A Arnica montana 6cH quando comparada ao Diclofenaco de Sódio 50mg se mostrou equivalente no controle do edema pós-cirúrgico.
Objective: To evaluate the Arnica montana 6 cH homeopathic efficacy compared to 50mg Diclofenac Sodium in the control of edema after removal of third molars. Methods: This work was an experimental, cross, randomized, double-blind study held on 30 volunteers student from the Dental School at the Sergipe Federal University, with the presence of impacted teeth on both sides, making a total of 120 teeth, indicating the same surgical technique. The groups were divided as follows: GROUP A: those who used the Arnica Montana 6cH and GROUP D: those who used 50mg Diclofenac Sodium. For edema measurement, we used a measure tape with which three measures were taken as reference: 1) eye corner to the tragus (EC-T); 2) eye corner to the jaw angle (EC-JA); 3) labial commissure to the tragus (LC-T). These were four times the first being shortly after the end of surgery and the remaining after 24h, 48h and 72h the end of surgery. Shapiro-Wilk test was used to verify the normal distribution of the studied variables. For normal distribution, Student test was used. The data were considered statistically significant when p less than 0.05. Results: In 48h post-surgery, the edema was notable for both groups in the segments EC-JA and LC-T. After 72h there was decrease of the edema for both drugs tested. The segment EC-T showed less edema for two medications. Student test showed that medications were similar anti-edematous efficacy (p greater than 0.05). Conclusions: The homeopathic remedy Arnica montana 6 cH has efficacy in controlling post-extraction edema of third molars. The Arnica montana 6cH compared to 50mg Diclofenac Sodium was equivalent to control postoperative edema.
Subject(s)
Humans , Diclofenac/adverse effects , Arnica/adverse effects , Students, Dental , Surgical Procedures, Operative , Surgery, Oral , Radiography, Panoramic/instrumentation , MolarABSTRACT
Son el resultado de la acción de determinados agentes externos capaces de actuar rápida e instantáneamente sobre el organismo, superando la resistencia de aquellos tejidos u órganos en los que directa o indirectamente recae su acción. Siendo una patología muy frecuente debido a la actual situación social y laboral (transporte, industria, deportes, etc).
Subject(s)
Humans , Arnica , Homeopathy , Multiple TraumaABSTRACT
Homeopathic medicine is becoming increasingly popular in this country and abroad. Arnica montana has been known since the 16th century as an acute topical treatment of sprains, bruises, painful swellings, and wounds. Although arnica has a long history in folk medicine and is widely used, efficacy in a decreasing of swelling and bruise has never been clinically studied. This study investigated the safety and efficacy of an Arnica montana gel, applied the twice daily, in 15 patients(6 men and 9 women) who had trauma with swelling and bruise without external wound of the face from April of 2006 through December of 2006. The trauma with swelling and bruise was made on the dorsum of the rat, and then applied the twice daily for 1 week divided in control site and arnica-applied site on the dorsum. On the patients' subjective assessment of efficacy, 15 patients felt an effect in 1 week, and time to onset of effect averaged 2.8 days. On the experimental study of efficacy, microscopic finding of control site showed the dermis is mildly widened interstitial spaces, the interstitial fluid is mildly increased, but arnica-applied site showed the interstitial edema is not evident, the dermal collagen fibers are relatively well preserved. Topical application of Arnica montana gel for 1 week was a safe, well-tolerated, and effective treatment of swelling and bruise of the face.
Subject(s)
Animals , Humans , Male , Rats , Arnica , Collagen , Contusions , Dermis , Edema , Extracellular Fluid , Medicine, Traditional , Sprains and Strains , Wounds and InjuriesABSTRACT
Arnica é o nome originalmente atribuído à espécie Arnica montana L.(Asteraceae), planta de origem Européia e utilizada em várias partes do mundo. A medicina tradicional brasileira atribui o nome de arnica também a outras espécies da família Asteraceae, especialmente algumas do gênero Lychnophora. No presente estudo foram determinadas as características físico-químicas (organoléptica, teor alcoólico, densidade, pH, porcentagem de resíduo seco) e químicas (CCD e CLAE) de tinturas preparadas com as arnicas L. pinaster e L. rupestris, em comparação com a A. montana. As amostras foram então submetidas a estudo de estabilidade, a partir da sua permanência em estufa climatizada por seis meses e em prateleira por 10 meses. Os resultados demonstraram alguma semelhança entre as tinturas de espécies de Lychnophora e a A. montana, especialmente entre seus perfis em CCD. Todas as tinturas sofreram alterações após o período de permanência na estufa, sendo o mais significante a redução no valor dos teores de resíduos secos, indicando degradação das substâncias e perda por volatilização. O conjunto das análises permitiu distinguir as tinturas de cada uma das espécies e confirmou a necessidade de determinar prazos de validade para as mesmas, devido à sua a instabilidade ao longo do tempo.
Arnica is the name attributed to Arnica montana L. (Asteraceae), an european species used in several parts of the world. The Brazilian traditional medicine also attributes the name of arnica to other species of the Asteraceae, especially some Lychnophora. In the present study physical-chemical characteristics (organoleptic, alcoholic graduation, density, pH, percentage of dry residue) and chemical (TLC and HPLC profiles) of tinctures prepared with L. rupestris, L. pinaster and A. montana has been determined. The samples had been then submitted the thermal stability testing. The results demonstrated some similarity between tinctures of the species of Lychnophora and A. montana, especially by their profiles in CCD. All tinctures altered after six months by thermal stability testing, being the most significant the reduction of percentage of dry residues, indicating degradation and loss of substances. The results allowed to distinguish tincture from the different species of arnica and confirmed their instability on the time.